Takaaki MATSUMOTO, M.D., Ph.D.

Associate Professor
The Second Department of Physiology
Aichi Medical University School of Medicine
Nagakute, Aichi 480-1195, Japan
E-mail: t-mat@aichi-med-u.ac.jp
phone : +81-561-62-3311
fax : +81-561-63-9809

• Mechanisms of long-term heat-acclimatization in tropical inhabitants
  Core temperature, skin temperatures and local sweat rates during heat load and the sweat gland response to ACh applied iontophoretically are compared between Japanese and tropical inhabitants (Thai and Africans). It was revealed that tropical inhabitants possess heat-tolerance due to enhanced dry heat loss such as radiation, convection and conduction and due to an avoidance of excess sweat loss (non-evaporating, ineffective sweating), which is convenient to maintain body fluid and osmolarity. Suppresion of sweating in tropical inhabitants is attributed to suppression in both central (upward threshold shift and decreased gain) and peripheral (decreased ACh-sensitivity of the sweat glands) sudomotor mechanism. This is a collaboration research with Department of Physiology, Chiang Mai University, Thailand.

• Mechanisms of diethylcarbamazine induced fever in the patients with filariasis
  
• Thermophysiological study on the pika as a cold- and high altitude-adapted animal
  

• Contribution of nitric oxide to adaptation of tibetan sheep to high altitude. Koizumi T, Ruan Z-H, Sakai A, Ishizaki T, Matsumoto T, Saito M, Matsuzaki T, Hubo K, Wang Z-G, Chen Q-H, Wang X-Q. Resp Physiol Neurobiol. 140(2): 189-196, 2004.
• Economical sweating function in Africans: Quantitative sudomotor axon reflex test. Lee JB, Bae JS, Choi JH, Ham JH, Min KY, Yang HM, Shimizu K, Matsumoto T. Korean J Physiol Pharmacol, 8: 21-25, 2004.
• Relationships between IgG, IgM, IgE and resistance to reinfection during the early phase of infection with Clonorchis sinensis in rats. F-S Quan, T Matsumoto, Y-O Shin, Y-K Min, H-M Yang, T Othman, J-B Lee. Immunol Inves, 33 (1): 51-60, 2004.
• Immunization with Trichinella spiralis Korean isolate larval excretory-secretory antigen induces protection and lymphocyte subset changes in rats. F-S Quan, T Matsumoto, J-B Lee, T Othman, J-S Lee, T-S Kim, K-H Joo, J-S Lee. Immunol Inves, 33 (1): 15-26, 2004.
• The role of RANTES in a murine model of food allergy. Lee JB, Matsumoto T, Yang HM, Min YK, Timothy O, Lee JS, Bae SJ, Quan FS. Immunol Invest, 33 (1): 27-38, 2004.

• Occurrence of the spinal reflex due to skin pressure in sudomotor and cutaneous vasoconstrictor nerve system of humans. Okagawa T, Sugenoya J, Iwase S, Mano T, Suzumura A, Matsumoto T, Sugiyama Y. Autonomic Neuroscience: Basic and Clinical, 105, 62-70, 2003.
• Cardiopulmonary hemodynamics of@blue-sheep,Pseudois nayaur, as high-altitude adapted mammals. Akio SAKAI, Takaaki MATSUMOTO, Muneo SAITOH, Tetsuya MATSUZAKI, Tomonobu, KOIZUMI, Takeshi ISHIZAKI, Zong Hai RUAN, Zhan Gang WANG, Qiu Hong CHEN and Xiao Qin WANG. Jpn J Physiol. 53(5): 377-384, 2003.

• Effects of repeated carbon dioxide-rich water bathing on core temperature, cutaneous blood flow and thermal sensation. Nishimura N, Sugenoya J, Matsumoto T, Kato M, Sakakibara H, Nishiyama T, Sakamoto (Inukai) Y, Okagawa T, Ogata A. Eur J Appl Physiol, 87, 337-342, 2002.
• Sudomotor modification by acclimatization of stay in temperate Japan of Malaysian native tropical subjects. Lee JB, Othman T, Lee JS, Quan FS, Choi JH, Min YK, Yang HM, Matsumoto T, Kosaka M. Jpn J Trop Med Hyg, 30(2), 295-299, 2002.

• Irregular activation of individual sweat glands in human sole observed by a videomicroscopy. Nishiyama T, Sugenoya J, Matsumoto T, Iwase S, Mano T. Autonomic Neuroscience: Basic and Clinical, 88, 117-126, 2001
• Hyperthermia enhancement of the apoptotic and antiproliferative activities of paclitaxel. Othman T, Goto S, Lee JB, Matsumoto T, Kosaka M. Pharmacol, 62(4), 208-212, 2001
• Sympathetic control of sweating and cutaneous active vasodilation. Sugenoya J, Matsumoto T, Nishiyama T, Sakamoto Y. In: Thermotherapy for Neoplasia, Imflamation, and Pain, Ed. Kosaka M, Sugahara T, Schmodt KL, Simon E. Springer-Verlag, Tokyo, 166-181, 2001
• Endcirne responses to heat and cold stress. Matsumoto T, Nishiyama T, Nishimura N, Kato M, Inumai Y, Sugenoya J. Yamauchi M and Kosaka M. In: Thermotherapy for Neoplasia, Imflamation, and Pain, Ed. Kosaka M, Sugahara T, Schmodt KL, Simon E. Springer-Verlag, Tokyo, 228-241, 2001
• Central and peripheral control of sweating mechanisms: Modifications by thermal acclimatization and physical training. Kosaka M, Othman T, Matsumoto T, Yamauchi M, Taimura A, Lee JB, Kaneda E and Ohwatari N. In: Thermotherapy for Neoplasia, Imflamation, and Pain, Ed. Kosaka M, Sugahara T, Schmodt KL, Simon E. Springer-Verlag, Tokyo, 95-106, 2001

• Antiproliferative efficacies of doxorubicin, verapamil, paclitaxel and quercetin in FM3A cells at hyperthermic temperature: A comparative assessment. Othman T, Goto S, Lee JB, Matsumoto T, Taimura A, Kaneda E, Ohwatari N, Kosaka M. Jpn J Hyperthermic Oncol, 16(1), 37-47, 2000
• Prior exposure of FM3A cells to quercetin enhanced the cytotoxic and apoptotic effects of hyperthermia. Othman T, Goto S, Lee JB, Nok A, Matsumoto T, Kosaka M. Jpn J Hyperthermic Oncol, 16(2), 99-115, 2000
• Thermal sweating responses during heat stress in swimmers. Taimura A, Matsumoto T, Sugawara M. J Phys Fit Nutr Immunol, 10(3), 170-174, 2000
• Endocrine responses to whole body hyperthermia in humans. Matsumoto T, Kosaka M, Lee JB, Nishiyama T, Nishumura N, Kato M, Inukai Y, Sugenoya J. The 8th International Congress of Hyperthermic Oncology Abstract Book, p.400, 2000
• Hsp mediated thermotolerance in temperature sensitive breast cancer cell line FM3A tsFT101. Cao Y, Matsumoto T, Motomura K, Ohtsuru A, Yamashita S, Kosaka M. The 8th International Congress of Hyperthermic Oncology Abstract Book, p.90, 2000
• Evaluation of the applicability of infrared and thermistor-thermometer in thermophysiology research. Lee JB, Kosaka M, Othman T,Matsumoto T, Motomura K, Nakase Y, Makita S. The 8th International Congress of Hyperthermic Oncology Abstract Book, p.136, 2000
• Prior treatment of FM3A mouse mammary cancer cells with quecrtin markedly increase their thermosensitivity. Othman T, Goto S, Lee JB, Matsumoto T, Nok A, Kosaka M. The 8th International Congress of Hyperthermic Oncology Abstract Book, p.195, 2000

• TGF-beta1 mediates 70-kDa heat shock protein induction due to ultraviolet irradiation in human skin fibroblasts. Cao Y, Ohwatari N, Matsumoto T, Kosaka M, Ohtsuru A and Yamashita S. Pflugers Arch, 438, 239-244, 1999
• Coactivation of the flexor muscles with the extensors during ballistic finger extension movement in kendo- and karate-athletes. Lee JB, Matsumoto T, Yamauchi M, Taimura A, Kaneda E, Ohwatari N and Kosaka M. Int J Sports Med, 20, 7-11, 1999
• Anatomical and neurochemical peculiarities of the pika retina: basis for lack of circadian rhythm of core temperature. Luo ZW, Kosaka M, Othman T, Piad JNC, Cao Y, Lee JB, Matsumoto T, Ohwatari N, Ichinose A, Mori K & Tonosaki A. Neurosci Lett, 259(1), 13-16, 1999
• Effects of fluid ingestion during intermittent high intensity swimming exercise on thermoregulatory responses and performance. Taimura A, Matsumoto T, Lee JB, Othman T, Yamauchi M, Sugahara M & Kosaka M. Trop Med, 41(2), 65-73, 1999
• Hyperthermia promote verapamil induced apoptotic and cytotoxic activities in FM3A murine mammary cancer cells. Othman T, Goto S, Lee JB, Matsumoto T, Kaneda E, Ohwatari N, Kosaka M. Jpn J Hyperthermic Oncol, 15(4), 211-218, 1999.

• Impared induction of heat shock protein implicated in decreased thermotolerance in a temperature-sensitive multinucleated cell line. Cao Y, Matsumoto T, Motomura K, Ohtsuru A, Yamashita S and Kosaka M. Pflugers Arch, 437, 15-20, 1998
• Rearing of plateau pika (Ochotona daurica) captured in Mongolia. Matsuzaki T, Saito M, Sakai A, Matsumoto T, Ganzorig S, Maeda Y. Exp Anim, 47(3), 203-206, 1998
• Heat shock proteins: roles in thermotolerance and as molecular targets for cancer therapy. Kosaka M, Othman T, Matsumoto T & Ohwatari N. Jpn J Hyperthermic Oncology, 14, 170-188, 1998

• Profilin gene expression and regulation in a temperature-sensitive breast cancer cell line: tsFM3A. Cao Y, Motomura K, Ohtsuru A, Matsumoto T, Yamashita S and Kosaka M. Pflugers Arch, 434, 341-345, 1997
• Analysis of sweat evaporation from clothing materials by ventilated sweat capsule method. Otomasu K, Yamauchi M, Ohwatari N, Matsumoto T, Tsuchiya K and Kosaka M. Eur J Appl Physiol, 76, 1-7, 1997
• Sweating economy by graded control in well-trained athletes. Yamauchi M, Matsumoto T, Ohwatari N and Kosaka M. Pflugers Arch, 433, 675-683, 1997
• Suppression of the sweat gland sensitivity to acethylcholine applied iontophoretically in tropical Africans compared to temperate Japanese. Lee JB, Matsumoto T, Othman T and Kosaka M. Trop Med, 39, 111-121, 1997
• Application of heterologous human skin graft to examination of human eccrine sweat gland. Shimazu M, Matsumoto T, Kosaka M, Ohwatari N, Tsuchiya K, Lee J-B, Ueyama Y, Urano K, Katakai Y and Saito M. In : Thermal Physiology 1997, Ed. B.J. Nielsen & R. Nielsen, August Krogh Institute, Copenhagen, 11-14, 1997
• Long-term heat acclimatization in tropical inhabitants. Matsumoto T, Taimura A, Yamauchi M, Lee JB, Kosaka M, Pongchaidecha A, Praputpittaya C, Gomonchareonsiri S, Boonayathap U and Sugenoya J. International Symposium on Thermal Physiology Abstracts, 69, 1997

• Insulative adaptation to cold and absence of circadian body temperature rhythm in Afghan pikas (Ochotona rufescens rufescens). Luo ZW, Matsumoto T, Ohwatari N, Shimazu M and Kosaka M. Trop Med, 38, 107-116, 1996
• Normal tympanic temperature measured with the infrared tympanic thermometer (Quick Thermo). Matsumoto T, Yamauchi M, Taimura A, Kaneda E, Tsuchiya K, Shimazu M, Cao Y, Luo ZW, Lee JB, Ohwatari N, Otomasu K and Kosaka M. Jpn J Biometeor, 33, 125-132, 1996
• Development of a disease model of diethylcarbamazine induced fever in the patients with filariasis. Matsumoto T, Luo ZW, Calvopina M, Fujimaki Y, Aoki Y and Kosaka M. XIVth International Congress for Tropical Medicine and Malaria Abstract, 59, 1996
• Antisense inhibition of parathyoid hormone-related peptide gene expression reduces malignant pituitary tumor progression and metastases in the rat. Akino K, Ohtsuru A, Yano H, Ozeki S, Namba H, Nakashima M, Ito M, Matsumoto T and Yamashita S. Cancer Res 56, 77-96, 1996
• A new approach to analysis of human sweating. Shimazu M, Matsumoto T, Kosaka M, Ohwatari N, Tsuchiya K, Ueyama Y, Urano K, Katakai Y and Saito M. Experientia, 52, 131-135, 1996

• Sweat responses in hyperthyroidism and hypothyroidism. Matsumoto T, Kosaka M, Yamauchi M, Ohwatari N, Tsuchiya K, Shimazu M, Otomasu K, Taimura A, Luo ZW, Cao Y, Kaneda E, Lee JB, Yamashita S, Izumi M and Nagataki S. In : Body Temperature and Metabolism ed by Nagasaka T & Milton AS, IPEC, 157-160, 1995
• A field study of telemetry-recording of the body temperature in wild Mongolian pikas. Matsumoto T, Kosaka M, Saito M, Sakai A, Matsuzaki T, Ganzorig S, Ohwatari N, Shimazu M and Nomura T. Trop Med, 37, 93-98, 1995
• Circadian and seasonal changes in metabolism, core temperature and circulation in the European hamster. Pleschka K, Ohwatari N, Hasegawa H, Matsumoto T and Vasile V. Pflugers Arch, 426(Suppl), R121, 1994

• Chiang Mai University, Thailand

• Xth International Symposium Pharmacology of Thermoregulation